CAP conducts humanitarian service missions, usually in support of the Red Cross but also assisting the State of Georgia and local municipalities. CAP aircrews transport time-sensitive medical materials, including blood and human tissue, when other means of transportation (such as ambulances) are not practical or possible. Following the September 11 attacks on the World Trade Center in New York City when all general aviation was grounded, one of the first planes to fly over the destroyed World Trade Center was a CAP aircraft taking photographs.
As a humanitarian service organization, CAP assists federal, state and local agencies in preparing for and responding to homeland security needs. In particular, the CAP fleet is used in training exercises to prepare USAF pilots to intercept enemy aircraft over the Continental United States. Civil Air Patrol aircraft are flown into restricted airspace, where Air Force F-16 Fighting Falcon and F-15 Eagle pilots may practice high-speed intercepts.
The Red American Cross, Salvation Army and other civilian agencies frequently ask Civil Air Patrol aircraft to transport vital supplies including medical technicians, medication, and other vital supplies. They often rely on CAP to provide airlift and communications for disaster relief. CAP also assists the United States Coast Guard and Coast Guard Auxiliary.